Manforce 50 mg Tablets Manforce 50 mg contains Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). During sexual stimulation, local release of nitric oxide (NO) activates guanylate cyclase, increasing intracellular concentrations of cGMP within the smooth muscle of the corpus cavernosum. Sildenafil selectively inhibits PDE5, preventing the enzymatic degradation of cGMP in penile vascular smooth muscle and facilitating cGMP accumulation. Elevated cGMP levels induce smooth muscle relaxation and arterial vasodilation within the erectile tissue, promoting increased blood flow to the corpus cavernosum to facilitate a natural erectile response. Manforce 50 mg is indicated for the treatment of erectile dysfunction (ED) in adult males.