VIDALISTA 40 Tablets VIDALISTA 40 contains Tadalafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). During sexual stimulation, local release of nitric oxide (NO) activates guanylate cyclase, increasing intracellular concentrations of cGMP within the vascular smooth muscle of the corpus cavernosum. Tadalafil selectively inhibits PDE5, preventing the enzymatic degradation of cGMP and promoting persistent smooth muscle relaxation, arterial vasodilation, and increased blood flow to the penile tissues. Due to its long elimination half-life, Tadalafil provides a prolonged duration of action of up to 36 hours. VIDALISTA 40 is indicated for the treatment of erectile dysfunction (ED) in adult males requiring a higher strength formulation.