Thymoglobuline 5mg Thymoglobuline contains Anti-Human Thymocyte Immunoglobulin (Rabbit), a purified, pasteurized, polyclonal IgG obtained by immunizing rabbits with human thymocytes. It contains antibodies directed against T-cell surface antigens (including CD2, CD3, CD4, CD8, CD11a, CD25, CD28, CD40, CD44, and CD45). Upon administration, it acts primarily through T-cell depletion in the blood and lymphoid tissues via complement-dependent lysis, opsonization, and cell-mediated apoptosis. It is indicated for the prevention and treatment of acute graft rejection in kidney, heart, liver, or pancreas transplantation, as well as for the treatment of steroid-resistant acute graft-versus-host disease (aGvHD) and severe aplastic anemia.