Tribenda 1000mg Tablets TRIBENDA 1000 contains Triclabendazole, a halogenated benzimidazole derivative with specific fasciolicidal activity. Triclabendazole acts by penetrating the parasite tegument and disrupting resting membrane potential, inhibiting tubulin binding, and decreasing resting muscle membrane voltage, which impairs protein synthesis and energy production in both immature and adult flukes. TRIBENDA 1000 is indicated as a high-strength formulation for the treatment and clinical management of fascioliasis (liver fluke infection caused by Fasciola hepatica or Fasciola gigantica).