TENVIR-EM Tablets TENVIR-EM contains Emtricitabine and Tenofovir Disoproxil Fumarate. Both components are synthetic nucleoside/nucleotide analogues of cytidine and adenosine 5'-monophosphate, respectively. Intracellularly, they are phosphorylated to their active metabolites, emtricitabine 5'-triphosphate and tenofovir diphosphate, which inhibit HIV-1 reverse transcriptase by competing with natural substrates and causing DNA chain termination. It is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients, as well as for pre-exposure prophylaxis (PrEP) in high-risk individuals to reduce the risk of sexually acquired HIV-1 infection.