Xapavir Tablets Xapavir contains Dolutegravir, a second-generation integrase strand transfer inhibitor (INSTI) with high barrier to resistance. Dolutegravir selectively binds to the active site of the retroviral integrase enzyme and interferes with the essential strand transfer step of viral integration. By blocking the integration of HIV-1 proviral DNA into the host cell genome, it halts the replication cycle of the virus. Xapavir is indicated in combination with other antiretroviral agents for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection in adult and pediatric patients weighing at least 20 kg.