Acabrunat 100 mg Acabrunat 100 mg is an oral anticancer medicine containing acalabrutinib, a targeted therapy used for certain types of B-cell blood cancers. It works by blocking a protein called BTK, which plays an important role in the growth and survival of abnormal B cells. By interfering with these signals, acalabrutinib helps slow the development and spread of cancerous B cells. It is taken under the supervision of an oncology specialist.