Bracanat 100 Tablets Bracanat 100 contains Olaparib, a targeted inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. By inhibiting PARP enzymatic activity and trapping PARP-DNA complexes, it prevents the repair of single-strand DNA breaks, converting them into double-strand breaks during replication. In cells with homologous recombination repair defects, such as BRCA1 or BRCA2 mutations, this leads to genomic instability and synthetic lethality. It is indicated for the treatment of advanced BRCA-mutated ovarian cancer, HER2-negative metastatic breast cancer, metastatic castration-resistant prostate cancer (mCRPC), and pancreatic adenocarcinoma.