Tipanat 15mg Tablets Tipanat 15 contains a combination of Trifluridine, a thymidine-based nucleoside analogue, and Tipiracil hydrochloride, a thymidine phosphorylase inhibitor. Trifluridine is incorporated into cellular DNA during replication, leading to DNA dysfunction and inhibition of cell proliferation. Tipiracil prevents the rapid degradation and metabolism of Trifluridine by inhibiting thymidine phosphorylase, thereby enhancing systemic exposure and antitumor efficacy of Trifluridine. Tipanat 15 is indicated for the treatment of adult patients with metastatic colorectal cancer and metastatic gastric or gastroesophageal junction adenocarcinoma who have been previously treated with or are not candidates for available standard therapies.