SAMTICA 500 mg Tablets SAMTICA 500 mg contains Abiraterone Acetate, a prodrug of abiraterone. It acts as a selective, irreversible inhibitor of 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme required for androgen biosynthesis across testicular, adrenal, and prostatic tumor tissues. Inhibiting CYP17 leads to severe suppression of serum testosterone concentrations. It is indicated, in combination with prednisone or prednisolone, for treating metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC).